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Identify clinically relevant p53-related long noncoding RNAs (lncRNAs) and assess their immune-related significance in colorectal cancer (CRC).

Novel p53-related lncRNAs as immune-associated biomarkers in colorectal cancer

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Identify clinically relevant p53-related long noncoding RNAs (lncRNAs) and assess their immune-related significance in colorectal cancer (CRC).
Analyzed RNA sequencing data from 483 CRC and 41 normal tissues in TCGA-COAD.
Used GEO datasets for validating differentially expressed genes and noncoding RNAs.
Conducted survival analysis with Cox regression to establish prognostic relevance.
Evaluated associations with immune cell infiltration using computational estimation methods.
Validated expression levels of key lncRNAs in paired CRC and adjacent normal tissues by quantitative real-time PCR.
Seventy-four p53-associated genes were consistently dysregulated across datasets.
Two lncRNAs, MIR23AHG and MIRLET7BHG, were upregulated and identified as potential biomarkers.
Both lncRNAs demonstrated moderate-to-good diagnostic performance with AUC values of 0.80 and 0.77.
Identified genes CD82, CDKN2A, and INHBB were linked to risk in survival analysis.
MIR23AHG and MIRLET7BHG showed significant associations with immune cell infiltration, particularly CD4⁺ T cells.

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Analysis identifies p53-related lncRNAs linked to immune responses in colorectal cancer, suggesting new biomarkers.

Jafari et al. (2026) studied this question.

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