Dual-catalytic system demonstrates efficient synthesis of glycomimetics from carbohydrates, indicating a novel approach.
Carbohydrates not only serve as energy sources for organisms but also perform numerous critical physiological functions. However, the inherent instability of O-glycosidic bonds restricts their application as therapeutic agents, and glycomimetics (including C-glycosides, branched-chain sugars, and carbasugars) have emerged as highly promising carbohydrate surrogates. We have developed a photoinduced hydrogen atom transfer (Photo-HAT)/nickel dual-catalytic system, which enables direct and stereoselective C(sp 3 )-H bond functionalization of carbohydrates, thereby providing a novel technology for the efficient synthesis of diverse rare sugars such as C-glycosides, branched-chain sugars, and carbasugars.
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Ping et al. (2026) studied this question.
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