In this issue, two research articles from St John’s University describe a thorough scientific approach to determine crucial aspects of excipient behavior for preparation of amorphous solid dispersions by hot melt extrusion. The approach combines a manufacturing process amendable for continuous manufacture with technology for improving drug solubility and bioavailability. Excipient properties are investigated in detail to elucidate differences between various grades of hydroxypropyl methylcellulose acetate succinate on formulation and processing performance. Kudos to the authors at St. John’s, this is the first issue of the IJPE that has one group providing all the scientific substrate.
Keith Horspool (Fri,) studied this question.