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The aim is to assess the biological differences in prostate cancer using dual-tracer PET/CT imaging.

Organ-Specific Heterogeneity and Discordance of 68Ga-PSMA-11 and 18F-FDG-PET/CT Characteristics in a Rapidly Progressive Poorly Differentiated Prostate Adenocarcinoma

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The aim is to assess the biological differences in prostate cancer using dual-tracer PET/CT imaging.
Presented a case of a 74-year-old male with Gleason score 9 prostate adenocarcinoma.
Utilized 68Ga-PSMA-11 and 18F-FDG PET/CT imaging for assessment.
Conducted histopathological examination to confirm diagnosis.
Notable differences observed between 68Ga-PSMA-11 and 18F-FDG PET/CT findings.
68Ga-PSMA-11 indicated PSMA-avid lesions, while 18F-FDG showed hypermetabolic liver metastases.
Histopathology confirmed poorly differentiated prostate adenocarcinoma, indicating tumor de-differentiation.

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A case report reveals inter-organ discrepancies in PET/CT characteristics of prostate cancer, suggesting therapy implications.

Jadhav et al. (2026) studied this question.

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