Retrospective immunohistochemistry study finds IL-31 and IL-31RA linked to inflammatory pathways in lichen planopilaris, suggesting potential for future research.
These findings suggest that increased IL-31 and IL-31RA expression in LPP is associated with neuroimmune signaling pathways involved in disease pathophysiology. Rather than indicating a disease-defining or diagnostic mechanism, IL-31/IL-31RA expression may represent an adjunctive immunologic feature within the broader inflammatory milieu of LPP and warrants further investigation in therapeutic and comparative studies.
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Gönüllü et al. (2026) studied this question.
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