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April 11, 2026Alimentary Pharmacology & Therapeutics4 citationsOpen Access

Diagnostic Impact of Liver Biopsy Among Antinuclear Antibody Positive Individuals With Mild Liver Enzyme Elevation

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DNDavid Mehdi Asgher NiaziACAlphonse CharbelJPJan Pfeiffenberger

Key Points

  • The aim is to assess the diagnostic value of liver biopsy in ANA-positive individuals with mild liver enzyme elevation.
  • Analyzed the diagnostic outcomes of liver biopsy in patients with alanine aminotransferase < 101 U/L
  • Identified patients who are non-cirrhotic and ANA-positive
  • Evaluated cases without alternative suspected aetiology
  • Liver biopsy offers limited additional diagnostic information in the studied population
  • The procedure can be safely deferred for patients with mild enzyme elevation
  • Biopsy is reserved for cases with higher enzyme levels or unclear diagnoses

Abstract

Liver biopsy provides limited additional diagnostic value in ANA-positive, non-cirrhotic patients with alanine aminotransferase < 101 U/L and no alternative suspected aetiology. In such cases, the procedure can be safely deferred, reserving biopsy for higher enzyme elevations or unclear differential diagnoses.

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Cite This Study

Niazi et al. (2026) studied this question.

synapsesocial.com/papers/69d9e62078050d08c1b765a2https://doi.org/10.1111/apt.70665
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