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This analysis reveals limited diagnostic value of liver biopsy in ANA-positive individuals with mild liver enzyme elevation, suggesting deferral for low-risk cases.
Liver biopsy provides limited additional diagnostic value in ANA-positive, non-cirrhotic patients with alanine aminotransferase < 101 U/L and no alternative suspected aetiology. In such cases, the procedure can be safely deferred, reserving biopsy for higher enzyme elevations or unclear differential diagnoses.
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Niazi et al. (2026) studied this question.
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