Speckle-based OCT reveals changes in retinal blood flow during IOP elevation in older individuals, suggesting implications for treatment.
Speckle-based OCT enables direct, quantitative assessment of retinal blood flow in vivo. Retinal perfusion remains stable through transient IOP elevations up to about 40 mm Hg, likely reflecting autoregulatory reserve, but declines at higher pressures. The relative flow preservation in older eyes may result from increased vascular wall rigidity. Speckle-based OCT provides a practical, quantitative method to assess retinal blood flow dynamics in vivo.
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Spaide et al. (2026) studied this question.
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