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This analysis compares survival outcomes between two surgical approaches for breast cancer, highlighting potential biases in patient selection.
In this study, which was designed to approximate a randomized trial as closely as possible, no significant difference in BCSS was observed between BCS+RT and mastectomy. Differences in OS likely reflect occult selection bias selection of patients with higher comorbidity burden to mastectomy.
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Wadsten et al. (2026) studied this question.
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