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April 11, 2026British journal of surgery1 citationsOpen Access

Survival after breast-conserving surgery and radiotherapy versus mastectomy: a propensity score-matched analysis within a randomized anaesthesiology trial

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CWCharlotta WadstenABA. BerglundESEmma Söderberg

Key Points

  • This analysis aims to investigate survival outcomes in breast cancer patients receiving either breast-conserving surgery with radiotherapy or mastectomy.
  • Conducted a propensity score-matched analysis to reduce bias.
  • Compared breast cancer-specific survival (BCSS) between treatment groups.
  • Analyzed overall survival (OS) considering patient comorbidities.
  • No significant difference in BCSS between breast-conserving surgery with radiotherapy and mastectomy.
  • Overall survival may differ due to selection bias toward mastectomy for higher comorbidity patients.

Abstract

In this study, which was designed to approximate a randomized trial as closely as possible, no significant difference in BCSS was observed between BCS+RT and mastectomy. Differences in OS likely reflect occult selection bias selection of patients with higher comorbidity burden to mastectomy.

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Cite This Study

Wadsten et al. (2026) studied this question.

synapsesocial.com/papers/69d9e64e78050d08c1b76b20https://doi.org/10.1093/bjs/znag036
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