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Finds decreased brain volumes linked to TDP-43 and cryptic RNA in Alzheimer's Disease, suggesting a role in volume loss.
MSD-TDP level is a reliable surrogate for IHC-based TDP-43 status. Both TDP-43 and cryptic RNA levels are associated with reduced medial temporal volumes, suggesting cryptic exons may be playing a role in brain volume loss in AD. ANN NEUROL 2026.
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Youssef et al. (2026) studied this question.
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