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May 10, 2024Journal of Alzheimer s DiseaseOpen Access

TDP-43 Is Associated with Subiculum and Cornu Ammonis 1 Hippocampal Subfield Atrophy in Primary Age-Related Tauopathy

Hossam Youssef Rodolfo G. Gatto Nha Trang Thu Pham Ronald C. Petersen Mary M. Machulda R. Ross Reichard Dennis W. Dickson Clifford R. Jack Jennifer L. Whitwell Keith A. Josephs

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Abstract

TAR DNA binding protein 43 (TDP-43) has been shown to be associated with whole hippocampal atrophy in primary age-related tauopathy (PART). It is currently unknown which subregions of the hippocampus are contributing to TDP-43 associated whole hippocampal atrophy in PART.

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Cite This Study

Youssef et al. (2024) studied this question.

synapsesocial.com/papers/68e6ab1eb6db64358762d398 https://doi.org/10.3233/jad-240136

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1TDP-43 Coincides with Noradrenergic Neurons in Alzheimer’s Disease (AD) and Primary Age-Related Tauopathy (PART)Cross-Sectional Study · 2026
2Comparative effects of TDP-43-A and TDP-43-α on hippocampal subfields and amygdala nucleiOriginal Research · 2026
3Biochemical and Immunohistochemical Associations of <scp>TDP</scp> ‐43 and Cryptic <scp>RNA</scp> With Hippocampal and Amygdala Volumetrics in Alzheimer's DiseaseOriginal Research · 2026
4Hippocampal subfield thickness and shape analysis in examining the impact of TDP‐43 in primary age‐related tauopathyOriginal Research · 2026
5Artificial intelligence–based <scp>3D</scp> segmentation of tangle‐associated <scp>TDP</scp> ‐43 in neurodegenerationOriginal Research · 2026 · 1 citations