Population
Human monocytic cell line THP-1 and primary human monocyte-derived macrophages
Design
Preclinical
Authors
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May alter phagocytosis with NaV1.5 blockade; leaves open its role in human cardiac inflammation.
Demonstrates a novel intracellular role for the cardiac sodium channel NaV1.5 in regulating macrophage endosomal acidification and phagocytosis.
Carrithers et al. (2007) studied this question.
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