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July 5, 2021International Heart JournalOpen Access

Efficacy and Safety of Aspirin Combined with Low-Dose P2Y12 Receptor Antagonists in East Asian Patients Undergoing PCI

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Why the study?

Whether low-dose new generation P2Y12 receptor antagonists are more suitable than standard-dose clopidogrel in DAPT for East Asian patients receiving PCI lacked consensus in clinical practice.

Does low-dose ticagrelor or prasugrel reduce MACEs without increasing bleeding compared to standard-dose clopidogrel in East Asian patients undergoing PCI?

Population

2,747 East Asian patients undergoing PCI across 8 RCT studies

Comparison

Low-dose P2Y12 receptor antagonists vs standard-dose clopidogrel

Design

Systematic review and meta-analysis of RCTs

Authors

XHXiankang HuWZWeibo ZhaoQZQiongyue Zhang

Discussion

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Overview

Supports low-dose ticagrelor or prasugrel over clopidogrel in East Asian PCI patients; extends evidence for ethnicity-specific P2Y12 dosing.

Structured PICO

Does low-dose ticagrelor or prasugrel reduce MACEs without increasing bleeding compared to standard-dose clopidogrel in East Asian patients undergoing PCI?

P
Population
2,747 East Asian patients undergoing percutaneous coronary intervention (PCI) pooled from 8 RCTs
I
Intervention
Low-dose new generation P2Y12 receptor antagonists (ticagrelor or prasugrel) combined with aspirin as dual antiplatelet therapy (DAPT)
C
Comparator
Standard-dose clopidogrel combined with aspirin as dual antiplatelet therapy (DAPT)
O
Outcome
Major adverse cardiac events (MACEs)composite

In East Asian patients undergoing PCI, low-dose ticagrelor or prasugrel provides superior efficacy in reducing MACEs compared to standard-dose clopidogrel without increasing bleeding risk.

Cite This Study

Hu et al. (2021) studied this question.

synapsesocial.com/papers/69d9fd9f8988aeabbe6864e3https://doi.org/10.1536/ihj.20-772
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Randomized Comparison of the Platelet Inhibitory Efficacy between Low Dose Prasugrel and Standard Dose Clopidogrel in Patients Who Underwent Percutaneous Coronary Intervention2014 · 12 citations