Regulatory review reports dimethylformamide restrictions and substitution strategies in chemical research, highlighting pathways to maintain safety and commercial viability.
As of December 2023, the use of common solvent N,N-dimethyl formamide (DMF) will be restricted in the European Union because of its reproductive health hazard. Industrial facilities must comply with stricter exposure limits, and researchers are recommended to find alternative solvents. Here we explain the restrictions on DMF, which disciplines are affected, and how to substitute DMF to keep research and development commercially relevant.
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Sherwood et al. (2024) studied this question.
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