Circulating mitochondrial DNA signature in cardiometabolic patients

Figures

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  Fig. 1. Distribution of the cell-free mtDNA and mtDNA ratio presented as violin plots showing median and interquartile range in patients with and without diabetes (A, B), with and without inflammation (C, D) and according to the absence or presence of increasing ultrasound (US) signs of congestion (E, F). Inflammation was defined as the co-presence of C-Reactive Protein ≥ 0.2 mg/dL and Neutrophil-Lymphocyte Ratio > 3

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  Fig. 2. Univariate correlation matrix using Spearman’s rank correlation. *P < 0.01, **P < 0.001, ***P < 0.0001. Red shading indicates positive correlations, and blue shading indicates inverse correlations. White boxes are non-significant (P > 0.05). eGFR: estimated glomerular filtration rate; VE: ventilation; VOC2: carbon dioxide production; VO2: oxygen consumption

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  Fig. 3. Receiver-operator characteristic (ROC) curves illustrating the accuracy of cell mtDNA, cell-free mtDNA and mtDNA ratio in predicting ≥ 2 ultrasound (US) signs of congestion and peak oxygen consumption (VO2) < 16 mL/kg/min. AUC: area under the curve