Is the circulating mitochondrial DNA signature altered in patients with HF and diabetes, and does it correlate with clinical parameters?
Circulating mitochondrial profile (cell-free mtDNA and mtDNA ratio) could serve as a novel biomarker of mitochondrial status, exercise capacity, inflammation, and congestion in cardiometabolic diseases.
Patients with HF and diabetes have an altered circulating mtDNA signature characterised by higher cell-free mtDNA and lower mtDNA ratio, whereas cellular mtDNA remains unaffected. Cell-free mtDNA and mtDNA ratio are associated with impaired response to exercise, higher systemic inflammation and increased congestion. Circulating mitochondrial profile could be a new biomarker of mitochondrial status in cardiometabolic diseases.
Mengozzi et al. (Wed,) studied this question.