Overriding the preference for favorable proximal metalation by ortho-directing amide group, a pyrimidine-based directing group (DG) has been demonstrated for diverse remote meta-C–H functionalizations of arenes including allylation, cyanation, alkylation, alkynylation, and deuteration. The scope of palladium-catalyzed meta-C–H functionalizations has been presented with various pharmaceutically relevant phenylacetic acid, hydrocinnamic acid, and naphthylacetic acid derivatives.
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Gholap et al. (2020) studied this question.
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