What question did this study set out to answer?

To systematically synthesize evidence on uremic serum- and uremic toxin-induced endothelial dysfunction and characterize the underlying molecular mechanisms in chronic kidney disease.

January 4, 2022SHILAP Revista de lepidopterologíaOpen Access

Impact of Uremic Toxins on Endothelial Dysfunction in Chronic Kidney Disease: A Systematic Review

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Authors

EHEva Harlacher JWJulia Wollenhaupt CBConstance C. F. M. J. Baaten

Discussion

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Overview

Systematic review reveals that uremic toxins drive endothelial dysfunction and vascular inflammation in chronic kidney disease, highlighting therapeutic targets for cardiovascular risk.

Key Points

To systematically synthesize evidence on uremic serum- and uremic toxin-induced endothelial dysfunction and characterize the underlying molecular mechanisms in chronic kidney disease.
Conducted a systematic review of literature focused on uremic serum and uremic toxin-mediated vascular and endothelial dysfunction, identifying 39 eligible studies.
Evaluated endothelial responses to specific toxins, including indoxyl sulfate, cyanate, modified LDL, advanced glycation end products, p-cresol, p-cresyl sulfate, phosphate, uric acid, and asymmetric dimethylarginine.
Most evaluated studies demonstrated that exposure to uremic conditions triggers endothelial inflammation, oxidative stress, leukocyte migration and adhesion, apoptosis, and a prothrombotic state.
Identified recurrent activation of key intracellular signaling cascades in damaged endothelial cells, predominantly the ROS, MAPK/NF-κB, aryl hydrocarbon receptor (AhR), and RAGE pathways.

Cite This Study

Harlacher et al. (2022) studied this question.

synapsesocial.com/papers/69da20089a6164e50fa3dc5d https://doi.org/10.3390/ijms23010531

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January 4, 2022SHILAP Revista de lepidopterologíaOpen Access

Impact of Uremic Toxins on Endothelial Dysfunction in Chronic Kidney Disease: A Systematic Review

View Full Paper

Ask AI

Bookmark

Authors

EHEva Harlacher JWJulia Wollenhaupt CBConstance C. F. M. J. Baaten

Discussion

Member takes

Overview

Systematic review reveals that uremic toxins drive endothelial dysfunction and vascular inflammation in chronic kidney disease, highlighting therapeutic targets for cardiovascular risk.

Key Points

To systematically synthesize evidence on uremic serum- and uremic toxin-induced endothelial dysfunction and characterize the underlying molecular mechanisms in chronic kidney disease.
Conducted a systematic review of literature focused on uremic serum and uremic toxin-mediated vascular and endothelial dysfunction, identifying 39 eligible studies.
Evaluated endothelial responses to specific toxins, including indoxyl sulfate, cyanate, modified LDL, advanced glycation end products, p-cresol, p-cresyl sulfate, phosphate, uric acid, and asymmetric dimethylarginine.
Most evaluated studies demonstrated that exposure to uremic conditions triggers endothelial inflammation, oxidative stress, leukocyte migration and adhesion, apoptosis, and a prothrombotic state.
Identified recurrent activation of key intracellular signaling cascades in damaged endothelial cells, predominantly the ROS, MAPK/NF-κB, aryl hydrocarbon receptor (AhR), and RAGE pathways.

Cite This Study

Harlacher et al. (2022) studied this question.

synapsesocial.com/papers/69da20089a6164e50fa3dc5d https://doi.org/10.3390/ijms23010531

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