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November 1, 2006Clinical Pharmacology & Therapeutics

Impact of P-glycoprotein on clopidogrel absorption

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Authors

DTDirk TaubertUniversity Hospital CologneNVN VONBECKERATHUniversity of CologneGGGundula GrimbergRutgers, The State University of New Jersey

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Implication

May explain variable clopidogrel response; leaves open whether MDR1 genotyping or P-gp modulation improves outcomes.

Key Points

  • To evaluate how P-glycoprotein efflux transport and the MDR1 C3435T genetic polymorphism alter clopidogrel absorption and subsequent active metabolite formation.
  • Assessed the impact of P-glycoprotein-mediated drug efflux on clopidogrel bioavailability.
  • Analyzed the relationship between the MDR1 C3435T genotype and active metabolite conversion.
  • P-glycoprotein efflux significantly restricts intestinal clopidogrel absorption.
  • Active metabolite formation is diminished and directly regulated by MDR1 C3435T genotype variations.

Structured PICO

I
Intervention
Clopidogrel
O
Outcome
Clopidogrel absorption and active metabolite formationsurrogate

P-glycoprotein efflux and the MDR1 C3435T genotype diminish clopidogrel absorption and active metabolite formation.

Cite This Study

Taubert et al. (2006) studied this question.

synapsesocial.com/papers/69da216d0d540cafc58386c2https://doi.org/10.1016/j.clpt.2006.07.007

Topics

Coronary artery diseaseDual antiplatelet therapy
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