Key result
In 180 patients, concomitant therapy with atorvastatin or simvastatin for ≥4 weeks did not impair the antiplatelet effect of a 600 mg loading dose of clopidogrel prior to coronary stenting.
Why the study?
Does concomitant atorvastatin or simvastatin therapy reduce the antiplatelet effect of a 600 mg loading dose of clopidogrel in patients undergoing coronary artery stenting?
Population
180 patients undergoing coronary artery stenting
Comparison
Concomitant statin therapy alongside a 600 mg… vs No statin therapy alongside a 600 mg loading…
Design
Cohort
Follow-up
At least 2 hours post-loading dose (prior to stenting)
Authors
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No attenuation seen in this cohort; leaves open whether statins blunt clopidogrel response in broader or randomized settings.
Cohort (n=180)
Does concomitant atorvastatin or simvastatin therapy reduce the antiplatelet effect of a 600 mg loading dose of clopidogrel in patients undergoing coronary artery stenting?
A 600 mg loading dose of clopidogrel maintains its full antiplatelet efficacy even in patients on chronic atorvastatin or simvastatin therapy prior to coronary stenting.
Olga Gorchakova (2004) conducted a cohort in Coronary artery stenting (n=180). Atorvastatin or simvastatin therapy vs. No statin therapy was evaluated on Inhibition of ADP-induced platelet aggregation and flow-cytometric parameters. In 180 patients, concomitant therapy with atorvastatin or simvastatin for ≥4 weeks did not impair the antiplatelet effect of a 600 mg loading dose of clopidogrel prior to coronary stenting.
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