The changing epidemiology of adult liver transplantation in the United States in 2013-2022: The dominance of metabolic dysfunction–associated steatotic liver disease and alcohol-associated liver disease
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Discussion
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Implication
Observational study reveals shifting etiologies toward fatty liver and alcohol-related conditions among adult liver transplant candidates, highlighting changing clinical burdens.
Key Points
- To assess shifting epidemiological patterns and primary disease etiologies among adult liver transplant recipients over a ten-year period.
- Retrospective epidemiological analysis evaluating adult liver transplant indications in the United States from 2013 through 2022.
- Stratified recipient etiologies based on the presence or absence of concurrent hepatocellular carcinoma (HCC).
- Alcohol-associated liver disease and NASH/MASH represent the two most frequent etiologies leading to transplantation in patients without hepatocellular carcinoma.
- NASH/MASH ranks as the single most common primary indication for liver transplantation among patients presenting with hepatocellular carcinoma.
Cite This Study
Younossi et al. (2023) studied this question.