Why the study?
Epidemiological data associate adiposity with cognitive dysfunction in older adults, prompting consideration of microvascular mechanisms underlying cognitive impairment in geriatric obesity.
Design
Review
Authors
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May implicate microvascular dysfunction in geriatric obesity-related cognitive decline; leaves open causal validation and intervention trials.
This review outlines the microvascular mechanisms linking geriatric obesity to cognitive decline, emphasizing the role of endothelial dysfunction and blood-brain barrier disruption.
Balasubramanian et al. (2020) studied this question.
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