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This research investigates how immune signatures in tumor samples can predict responses to immune checkpoint blockade.

June 15, 2016Cancer DiscoveryOpen Access

Analysis of Immune Signatures in Longitudinal Tumor Samples Yields Insight into Biomarkers of Response and Mechanisms of Resistance to Immune Checkpoint Blockade

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Randomized trial demonstrates predictive immune signatures in tumor samples, indicating implications for cancer treatment.

This research investigates how immune signatures in tumor samples can predict responses to immune checkpoint blockade.
Analyzed early on-treatment tumor biopsies for immune signatures
Evaluated association of immune signatures with treatment response
Explored mechanisms of resistance in various cancer types.
Adaptive immune signatures predict response to checkpoint blockade
Insights gained into mechanisms of therapeutic resistance
Implications for enhancing precision medicine in cancer treatment.

Chen et al. (2016) studied this question.

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