Delay of treatment initiation is the single most important modifiable risk factor for developing refractory rheumatoid arthritis.
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Our data identified delay to initial treatment, female gender and higher disease activity as important predictors of a later refractory course of RA. Delay of treatment initiation is the single most important modifiable risk factor of refractory disease.
May support earlier RA treatment to lower refractory risk; leaves open causal confirmation in trials.
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Bécède et al. (2019) studied this question.
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