What question did this study set out to answer?

To assess evidence for the extra-skeletal health benefits of vitamin D and identify optimal serum 25-hydroxyvitamin D concentrations and supplementation recommendations.

January 14, 2025NutrientsOpen Access

Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines

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Authors

WGWilliam B. GrantSunlight Nutrition and Health Research Center SWSunil J. WimalawansaBrunswick (United States)PPPaweł PłudowskiChildren's Memorial Health Institute

Discussion

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Implication

Narrative review demonstrates extra-skeletal disease reduction with higher vitamin D levels in general populations, highlighting the need to revise clinical intake guidelines.

Key Points

To assess evidence for the extra-skeletal health benefits of vitamin D and identify optimal serum 25-hydroxyvitamin D concentrations and supplementation recommendations.
Synthesized findings from prospective cohort studies and randomized controlled trials evaluating the association between serum 25-hydroxyvitamin D concentrations and health outcomes.
Assessed population deficiency prevalence and evaluated clinical trial designs regarding baseline serum thresholds and supplementation dosages.
Serum 25-hydroxyvitamin D concentrations greater than 30 ng/mL (75 nmol/L) significantly reduce risks of major diseases and all-cause mortality compared to levels below 20 ng/mL.
Achieving serum levels above 30 ng/mL requires daily supplementation of 2000 IU (50 mcg) of vitamin D3, whereas 4000 to 6000 IU daily achieves target concentrations of 40 to 70 ng/mL for enhanced protection.

Cite This Study

Grant et al. (2025) studied this question.

synapsesocial.com/papers/69da246a84371aa676a3cbe2 https://doi.org/10.3390/nu17020277

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Implication

Narrative review demonstrates extra-skeletal disease reduction with higher vitamin D levels in general populations, highlighting the need to revise clinical intake guidelines.

Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines

Discussion

Member takes

Implication

Key Points

Cite This Study

Vitamin D: Evidence-Based Health Benefits and Recommendations for Population Guidelines

Discussion

Member takes

Implication

Key Points

Cite This Study

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