What question did this study set out to answer?

To investigate whether distinct cognitive subtypes exist in minimally medicated patients with recent onset psychosis and identify their underlying gray matter volume patterns and clinical characteristics.

March 15, 2021NeuropsychopharmacologyOpen Access

Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?

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Authors

JWJulian WenzelUniversity of Cologne SHShalaila S. HaasLudwig-Maximilians-Universität München DDDominic DwyerOrygen Youth Health

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Implication

Multicenter study reveals distinct impaired and spared cognitive subtypes in recent onset psychosis, highlighting divergent brain volume patterns and a potential neurodevelopmental origin.

Key Points

To investigate whether distinct cognitive subtypes exist in minimally medicated patients with recent onset psychosis and identify their underlying gray matter volume patterns and clinical characteristics.
Applied a K-means clustering algorithm to cognitive performance data from 108 psychosis patients in the multi-site EU PRONIA study, validating findings in an independent sample (N = 53).
Classified cognitive subgroups and healthy controls (n = 195) based on gray matter volume using Support Vector Machine classification.
Clustering identified cognitively spared (N = 67) and impaired (N = 41) subgroups, validated in N = 40 spared and N = 13 impaired; the impaired group had worse negative symptoms (pfdr = 0.003), cognition (pfdr < 0.001), and functioning (pfdr < 0.035).
Impaired patients demonstrated persistent deficits across verbal memory and processing speed in both discovery and validation cohorts.
Gray matter volume patterns distinguished impaired patients from healthy controls with 60.1% balanced accuracy (p = 0.01), showing structural differences across fronto-temporal-parietal regions, basal ganglia, and cerebellum.

Cite This Study

Wenzel et al. (2021) studied this question.

synapsesocial.com/papers/69da251ba6045d71bfa3c37d https://doi.org/10.1038/s41386-021-00963-1

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Implication

Multicenter study reveals distinct impaired and spared cognitive subtypes in recent onset psychosis, highlighting divergent brain volume patterns and a potential neurodevelopmental origin.

Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?

Discussion

Member takes

Implication

Key Points

Cite This Study

Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?

Discussion

Member takes

Implication

Key Points

Cite This Study

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