What question did this study set out to answer?

The aim is to develop a technique for imaging intact human organs at cellular resolution in 3D.

November 4, 2021Nature MethodsOpen Access

Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography

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Randomized trial demonstrates imaging cellular structures in human organs, highlighting significant advances in biomedical imaging.

The aim is to develop a technique for imaging intact human organs at cellular resolution in 3D.
Developed hierarchical phase-contrast tomography (HiP-CT) using X-ray phase propagation.
Performed 3D non-destructive scans of five intact human organ types: brain, lung, heart, kidney, and spleen.
Utilized the European Synchrotron Radiation Facility’s Extremely Brilliant Source for enhanced imaging quality.
HiP-CT provided comprehensive structural overviews of each organ and detailed high-resolution images.
Captured functional units and specialized cells within organs, including glomeruli in kidneys.
Identified regional changes in lung tissue architecture related to COVID-19 in a deceased donor.

Walsh et al. (2021) studied this question.

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