Does pioglitazone improve histological response and adipose tissue insulin resistance in patients with nonalcoholic steatohepatitis?
Pioglitazone-induced improvement in adipose tissue insulin resistance correlates with histological improvement in patients with NASH.
Patients with NASH have severe Adipo-IR independent of the degree of obesity. Amelioration of Adipo-IR by pioglitazone is closely related to histological improvement and plays an important role during treatment of patients with NASH.
Gastaldelli et al. (Tue,) studied this question.
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