Key result
Higher adipose tissue insulin resistance in obese patients with NAFLD was associated with worse metabolic parameters, hepatic insulin resistance, and liver fibrosis (P<0.01).
Population
207 obese patients with nonalcoholic fatty liver disease and 22 controls without NAFLD
Design
Cross-sectional
Authors
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Should not yet change NAFLD management; hypothesis-generating for adipose insulin resistance as a fibrosis target.
Observational (n=229)
p-value: p=<0.01
Adipose tissue insulin resistance is strongly associated with metabolic abnormalities and liver fibrosis in obese patients with NAFLD.
Lomonaco et al. (2011) conducted an observational in Nonalcoholic fatty liver disease (n=229). Adipose tissue insulin resistance vs. Controls without NAFLD and lower quartiles of insulin resistance was evaluated on Metabolic parameters, hepatic insulin resistance, and liver fibrosis (p=<0.01). Higher adipose tissue insulin resistance in obese patients with NAFLD was associated with worse metabolic parameters, hepatic insulin resistance, and liver fibrosis (P<0.01).
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