What question did this study set out to answer?

To engineer an oxygen-boosted cascade nanoreactor that overcomes tumor hypoxia to enhance glucose starvation, oxidative damage, and cancer stem cell eradication in aggressive breast cancer.

April 28, 2023Advanced ScienceOpen Access

Hyperbaric Oxygen Activates Enzyme‐Driven Cascade Reactions for Cooperative Cancer Therapy and Cancer Stem Cells Elimination

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Authors

YXYuxuan XiongShanghai Jiao Tong University ZYZhengtao YongHuazhong University of Science and Technology XCXu ChenNanjing Agricultural University

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Implication

Preclinical study demonstrates that hyperbaric oxygen combined with cascade bioreactors suppresses primary tumors and pulmonary metastases in breast cancer models, suggesting strong translational...

Key Points

To engineer an oxygen-boosted cascade nanoreactor that overcomes tumor hypoxia to enhance glucose starvation, oxidative damage, and cancer stem cell eradication in aggressive breast cancer.
Assembled a pH-responsive multifunctional bioreactor (HCG) using hydroxyethyl starch prodrugs, copper ions, and glucose oxidase.
Applied hyperbaric oxygen to alleviate tumor hypoxia, stimulate glucose-depleting enzymatic reactions, generate toxic reactive oxygen species, and degrade dense tumor matrix.
Evaluated primary tumor growth suppression, pulmonary metastasis inhibition, and cancer stem cell clearance in orthotopic breast cancer models.
Hyperbaric oxygen alleviated intratumoral hypoxia, triggering glucose oxidase to deplete glucose and generating hydrogen peroxide that accelerated copper-catalyzed hydroxyl radical production.
Hyperbaric oxygen degraded the dense tumor extracellular matrix, promoting enhanced nanoreactor accumulation, tissue penetration, and cellular antioxidant depletion.
The combination therapy markedly suppressed orthotopic breast tumor progression and prevented lung metastasis by selectively eliminating cancer stem cells.

Cite This Study

Xiong et al. (2023) studied this question.

synapsesocial.com/papers/69da28e2a6045d71bfa3c53b https://doi.org/10.1002/advs.202301278

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Implication

Preclinical study demonstrates that hyperbaric oxygen combined with cascade bioreactors suppresses primary tumors and pulmonary metastases in breast cancer models, suggesting strong translational...

Hyperbaric Oxygen Activates Enzyme‐Driven Cascade Reactions for Cooperative Cancer Therapy and Cancer Stem Cells Elimination

Discussion

Member takes

Implication

Key Points

Cite This Study

Hyperbaric Oxygen Activates Enzyme‐Driven Cascade Reactions for Cooperative Cancer Therapy and Cancer Stem Cells Elimination

Discussion

Member takes

Implication

Key Points

Cite This Study

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