Why the study?
Does caveolin-1 gene knockout affect cardiopulmonary function in mice?
Population
mice deficient in the caveolin-1 (cav-1) gene (cav-1(-/-) mice)
Design
Preclinical
Authors
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Caution against clinical translation from this animal model; leaves open caveolin-1 as a research target in human cardiopulmonary disease.
Does caveolin-1 gene knockout affect cardiopulmonary function in mice?
Caveolin-1 is essential for the control of systemic NO levels and normal cardiopulmonary function in vivo.
Zhao et al. (2002) studied this question.
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