March 1, 2002Journal of Biological ChemistryOpen Access

Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities

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Population

Caveolin-1-deficient (Cav-1 null) mice and wild-type controls

Comparison

High fat diet vs Wild-type controls on high fat diet

Design

Preclinical

Authors

BRBabak RazaniGeneral Cardiology TCTerry P. CombsUniversity of North Carolina at Chapel Hill XWXiaobo WangSouth China Agricultural University

Discussion

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Implication

Caveolin-1 targeting may risk hypertriglyceridemia despite anti-obesity effects in mice; leaves open human applicability.

Structured PICO

Population

Caveolin-1-deficient (Cav-1 null) mice and wild-type controls

Intervention

High fat diet

Comparator

Wild-type controls on high fat diet

Outcome

Body weight, adipocyte morphology, and serum lipid levels (triglycerides, free fatty acids, cholesterol)surrogate

Caveolin-1 deficiency in mice confers resistance to diet-induced obesity but causes severe hypertriglyceridemia, highlighting its role in systemic lipid homeostasis.

Cite This Study

Razani et al. (2002) studied this question.

synapsesocial.com/papers/69da28fe0f778bd2e46845a3 https://doi.org/10.1074/jbc.m110970200

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Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Caveolin-1-deficient Mice Are Lean, Resistant to Diet-induced Obesity, and Show Hypertriglyceridemia with Adipocyte Abnormalities

Discussion

Member takes

Implication

Structured PICO

Cite This Study

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