September 28, 2001Science

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

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Population

Caveolin-1 gene-disrupted mice

Design

Preclinical

Authors

MDMarek DrábMax Planck Society PVPaul VerkadeUniversity of Pisa MEMarlies ElgerHeidelberg University

Discussion

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Implication

Should not yet change practice; hypothesis-generating for caveolin-1 in human endothelial and fibrotic disease.

Structured PICO

Population

Caveolin-1 gene-disrupted mice

Intervention

Targeted disruption of the caveolin-1 gene

Outcome

Cardiovascular system function (nitric oxide and calcium signaling, endothelium-dependent relaxation, contractility, myogenic tone) and lung pathologysurrogate

Caveolin-1 and caveolae are essential for organizing multiple signaling pathways, including nitric oxide and calcium signaling in the cardiovascular system.

Cite This Study

Dráb et al. (2001) studied this question.

synapsesocial.com/papers/69da28fe0f778bd2e46845a4 https://doi.org/10.1126/science.1062688

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Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Loss of Caveolae, Vascular Dysfunction, and Pulmonary Defects in Caveolin-1 Gene-Disrupted Mice

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider