Why the study?
Do circulating microRNA changes differ between responders and non-responders to Cardiac Resynchronization Therapy in heart failure patients?
Do circulating microRNA changes differ between responders and non-responders to Cardiac Resynchronization Therapy in heart failure patients?
Favorable changes in circulating miRNAs regulating fibrosis, apoptosis, and hypertrophy are associated with reverse remodeling in heart failure patients responding to CRT.
Answers are grounded in this paper and cite their sources.
miRNA shifts linked to reverse remodelling support mechanistic insights into CRT response; hypothesis-generating and should not yet change practice.
In responders, reverse remodelling is associated with favourable changes in miRNAs that regulate cardiac fibrosis, apoptosis, and hypertrophy.
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Marfella et al. (2013) studied this question.
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