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Review the physiological mechanisms of sweat gland function, explore thermoregulatory and non-thermoregulatory roles of sweating, and assess sweat composition's utility in human health monitoring.

June 15, 2019TemperatureOpen Access

Physiology of sweat gland function: The roles of sweating and sweat composition in human health

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Authors

LBLindsay B. BakerPepsiCo (United Kingdom)

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Implication

Comprehensive review reveals sweat primarily drives thermoregulation rather than toxicant excretion in humans, highlighting limited utility of sweat as a standalone clinical biomarker.

Key Points

Review the physiological mechanisms of sweat gland function, explore thermoregulatory and non-thermoregulatory roles of sweating, and assess sweat composition's utility in human health monitoring.
Comprehensive literature review evaluating physiological evidence on human eccrine sweat gland function, thermoregulatory adaptation, solute excretion, and biomarker potential.
Sweating plays a negligible role in clearing metabolic wastes and toxicants relative to renal and gastrointestinal clearance, with eccrine glands lacking mechanisms to concentrate waste or selectively upregulate excretion.
Eccrine sweat glands do not perform vasopressin-mediated water reabsorption, though elevated sweat sodium chloride concentrations markedly increase electrolyte imbalance risk in conditions like cystic fibrosis.
The clinical utility of sweat composition as a diagnostic biomarker remains unproven due to insufficient evidence correlating sweat solute concentrations with circulating blood solute levels.

Cite This Study

Lindsay B. Baker (2019) studied this question.

synapsesocial.com/papers/69da3b4aba6014a02e83683b https://doi.org/10.1080/23328940.2019.1632145

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Implication

Comprehensive review reveals sweat primarily drives thermoregulation rather than toxicant excretion in humans, highlighting limited utility of sweat as a standalone clinical biomarker.

Physiology of sweat gland function: The roles of sweating and sweat composition in human health

Discussion

Member takes

Implication

Key Points

Cite This Study

Physiology of sweat gland function: The roles of sweating and sweat composition in human health

Discussion

Member takes

Implication

Key Points

Cite This Study

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