Why the study?
Does infection with a virus encoding a myelin epitope mimic initiate organ-specific T cell-mediated autoimmunity in SJL/J mice?
Population
SJL/J mice
Comparison
Infection with a nonpathogenic Theiler's murine… vs Infection with TMEV encoding a non-self…
Design
Preclinical
Follow-up
10-14 days
Authors
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Should not yet influence clinical infection management; leaves open whether viral myelin mimics initiate human autoimmunity.
Does infection with a virus encoding a myelin epitope mimic initiate organ-specific T cell-mediated autoimmunity in SJL/J mice?
This study provides the first evidence that a naturally infectious virus encoding a myelin epitope mimic can directly initiate organ-specific T cell-mediated autoimmunity.
Olson et al. (2001) studied this question.
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