May 1, 1996The Journal of Immunology

Streptococcal M protein peptide with similarity to myosin induces CD4+ T cell-dependent myocarditis in MRL/++ mice and induces partial tolerance against coxsakieviral myocarditis

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Why the study?

Does tolerization to streptococcal NT4 peptide prevent CVB3-induced myocarditis in MRL/++ mice?

Population

MRL/++ (H-2k) mice

Comparison

Immunization with streptococcal NT4 peptide or… vs Control peptide VP1-10 from the CVB3 capsid…

Design

Preclinical

Follow-up

7 days

Authors

SHSally A. HuberUniversity of Vermont MCMadeleine W. CunninghamGeneral Cardiology

Discussion

Member takes

Implication

NT4 tolerization merits further study in viral myocarditis models; leaves open any role in human disease.

Structured PICO

Does tolerization to streptococcal NT4 peptide prevent CVB3-induced myocarditis in MRL/++ mice?

Population

MRL/++ (H-2k) mice

Intervention

Immunization with streptococcal NT4 peptide or tolerization via injection of NT4 covalently coupled to syngeneic splenocytes

Comparator

Control peptide VP1-10 from the CVB3 capsid protein VP1

Outcome

Development of myocarditis / cardiac inflammationsurrogate

Immunity to the streptococcal NT4 peptide induced during CVB3 infections plays an important role in the development of cardiac inflammation, and tolerization to this peptide reduces myocarditis.

Cite This Study

Huber et al. (1996) studied this question.

synapsesocial.com/papers/69da3ed33e67f8d13868445e https://doi.org/10.4049/jimmunol.156.9.3528

Topics

Myocarditis

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