Population
100 specimens of unfixed washed sections of auricular appendages from rheumatic hearts, along with control…
Comparison
Fluorescent antibody methods to detect bound… vs Control hearts from normal and pathologic material
Design
Preclinical
Authors
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Supports immune-mediated pathology in rheumatic hearts; hypothesis-generating and requires prospective human validation before any clinical inference.
The deposition of gamma globulin in rheumatic heart tissue suggests an immunologic component to the pathologic changes seen in rheumatic heart disease.
Kaplan et al. (1961) studied this question.
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