Temporal changes of the plasma levels of cystatin C, β‐trace protein, β₂‐microglobulin, urate and creatinine during pregnancy indicate continuous alterations in the renal filtration process

The albumin levels decreased in the second and third trimesters, whereas the levels of chi2-macroglobulin were unchanged, which is compatible with a virtually unaltered transfer of chi2-macroglobulin between the intra- and extravascular space during pregnancy and a significantly increased extravascular fraction of albumin.