Declines in Mortality Rates and Changes in Causes of Death in HIV-1-Infected Children During the HAART Era

Overall death rates declined from 1993 to 2000 but have since stabilized at rates about 30 times higher than for the general US pediatric population. Deaths due to OIs have declined, but non-AIDS-defining infections and multiorgan failure remain major causes of mortality in HIV-1-infected children.