Recent Advances in Direct C–H Functionalization of Pyrimidines

Data spanning the period 2000–2017 on the direct C–H functionalization of pyrimidines are collected and discussed in this review. This demonstrates the surge of interest and creativity that this field of chemistry has experienced during the last two decades. Plausible applications of highly functionalized pyrimidines are also discussed. 1 Introduction 2 Transition-Metal-Catalyzed C–H Functionalization of Pyrimidine Derivatives 3 Transition-Metal-Free Direct C–H Functionalization of Pyrimidine Derivatives 4 Deprotonative Metalation of Pyrimidine Derivatives 5 Conclusions