Observational analysis demonstrates elevated glucose and insulin levels link to lower muscle mass, suggesting impaired glycemic control accelerates age-related muscle loss.
Higher fasting and OGTT values of both glucose and insulin are associated with lower muscle mass. Longitudinal studies are needed to verify whether individuals free of diabetes that have higher glucose and insulin during an OGTT are at risk for accelerated muscle mass decline with aging.
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Kalyani et al. (2011) studied this question.
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