Why the study?
Do ROCK inhibitors improve cardiac remodeling and prevent heart failure?
Do ROCK inhibitors improve cardiac remodeling and prevent heart failure?
This review highlights the therapeutic potential of ROCK inhibitors, such as fasudil, in mitigating deleterious cardiac remodeling, fibrosis, and hypertrophy.
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ROCK inhibition may attenuate remodeling; leaves open whether inhibitors improve heart failure outcomes.
Shimizu et al. (2016) studied this question.
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