Does overexpression of catalase targeted to mitochondria attenuate cardiac aging and improve survival in mice?
This study highlights the critical role of mitochondrial reactive oxygen species in cardiac aging and supports the potential therapeutic application of mitochondrial antioxidants.
This study shows that cardiac aging in the mouse closely recapitulates human aging and demonstrates the critical role of mitochondrial reactive oxygen species in cardiac aging and the impact of cardiac aging on survival. These findings also support the potential application of mitochondrial antioxidants in reactive oxygen species-related cardiovascular diseases.
Dai et al. (Tue,) studied this question.
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