Why the study?
Does overexpression of catalase targeted to mitochondria attenuate cardiac aging and improve survival in mice?
Does overexpression of catalase targeted to mitochondria attenuate cardiac aging and improve survival in mice?
This study highlights the critical role of mitochondrial reactive oxygen species in cardiac aging and supports the potential therapeutic application of mitochondrial antioxidants.
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Hypothesis-generating for mitochondrial antioxidants in cardiac aging; leaves open translation to human disease.
Dai et al. (2009) studied this question.
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