August 18, 2010The Journal of Pathology

Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF‐β1 synthesis

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Population

Uninephrectomized mice

Comparison

Asymmetric dimethylarginine 60 mg/kg per day… vs Isotonic saline and NG-nitro-L-arginine methyl…

Design

Preclinical

Follow-up

8 weeks

Authors

FMFabrice MihoutCentre Hospitalier Universitaire de Lille NSNasim ShwekeInserm NBNaïke BigéHôpital Necker-Enfants Malades

Discussion

Member takes

Implication

Animal data link ADMA to renal fibrosis and hypertension; hypothesis-generating for CKD mechanisms, translation unproven.

Structured PICO

Population

Uninephrectomized mice

Intervention

Asymmetric dimethylarginine (ADMA) 60 mg/kg per day infused through osmotic mini-pumps for 8 weeks

Comparator

Isotonic saline (control) and NG-nitro-L-arginine methyl ester (L-NAME) 60 mg/kg per day infused through osmotic mini-pumps for 8 weeks

Outcome

Renal structure and fibrosis (deposits of collagen I, III, and fibronectin)surrogate

Elevated concentrations of ADMA induce renal fibrosis and hypertension, suggesting a mechanistic role in chronic kidney disease progression.

Cite This Study

Mihout et al. (2010) studied this question.

synapsesocial.com/papers/69da7e40ae64bec32b836015 https://doi.org/10.1002/path.2769

Topics

Hypertension management

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Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF‐β1 synthesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Asymmetric dimethylarginine (ADMA) induces chronic kidney disease through a mechanism involving collagen and TGF‐β1 synthesis

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider