Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
December 2, 2014World Journal of Surgery

The Impact of Anastomotic Leak and Its Treatment on Cancer Recurrence and Survival Following Elective Colorectal Cancer Resection

View Full Paper
Ask AI
Bookmark
Share

Why the study?

Does anastomotic leak requiring reoperation affect overall survival and disease-free survival in patients following elective colorectal cancer resection?

Population

Patients following elective colorectal cancer resection

Comparison

Anastomotic leak requiring reoperation vs Patients who do not leak

Design

Cohort

Authors

SNSubramanian NachiappanEast Kent Hospitals University NHS Foundation TrustAAAlan AskariApple (Israel)GMGeorge MalietzisBicycle Therapeutics (United Kingdom)

Discussion

Loading...

Member takes

Implication

Anastomotic leak requiring reoperation was associated with worse OS but not DFS after colorectal resection; leaves open causality and needs prospective confirmation.

Structured PICO

Does anastomotic leak requiring reoperation affect overall survival and disease-free survival in patients following elective colorectal cancer resection?

P
Population
Patients following elective colorectal cancer resection
I
Intervention
Anastomotic leak requiring reoperation
C
Comparator
Patients who do not leak
O
Outcome
Overall survival (OS) and disease-free survival (DFS)hard clinical

Anastomotic leaks requiring reoperation after elective colorectal cancer resection are associated with worse overall survival but do not significantly impact disease-free survival.

Cite This Study

Nachiappan et al. (2014) studied this question.

synapsesocial.com/papers/69da7fce387cf70698686d13https://doi.org/10.1007/s00268-014-2887-2
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Impact of Postoperative Complications on Long-term Survival After Resection for Rectal Cancer2012 · 38 citations
  2. 2Impact of early reoperation after resection for colorectal cancer on long‐term oncological outcomes2011 · 22 citations
  3. 3Risk Factors and Outcomes for Anastomotic Leakage in Colorectal Surgery: A Single‐Institution Analysis of 1576 Patients2010 · 219 citations
  4. 4Determinants of Long-Term Survival After Major Surgery and the Adverse Effect of Postoperative Complications2005 · 1,479 citations
  5. 5Predicting the risk and diminishing the consequences of anastomotic leakage after anterior resection for rectal cancer2010 · 37 citations