March 1, 1987Annals of Internal Medicine
Functional Renal Insufficiency During Long-Term Therapy with Captopril and Enalapril in Severe Chronic Heart Failure
Why the study?
Does treatment with captopril or enalapril cause functional renal insufficiency in patients with severe chronic heart failure?
Population
104 patients with severe chronic heart failure
Design
Cohort
Follow-up
1 to 3 months
Authors
Discussion
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Member takes
Implication
Functional renal insufficiency on ACE inhibitors in severe HF may reflect excessive pressure reduction and respond to less diuretic; leaves open prospective confirmation.
Structured PICO
Does treatment with captopril or enalapril cause functional renal insufficiency in patients with severe chronic heart failure?
P
Population
104 patients with severe chronic heart failure
I
Intervention
Captopril or enalapril (converting-enzyme inhibition)
O
Outcome
Change in renal function (development of functional renal insufficiency)safety
Deterioration of renal function after ACE inhibition in severe heart failure is hemodynamically mediated and can be reversed by reducing diuretic dosage.
Cite This Study
Packer et al. (1987) studied this question.