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Direct interaction between the KCNQ1-KCNE1 channel and microtubules is required for PKA-dependent I(Ks) activation, providing mechanistic insight into cardiac electrophysiology.
We propose that the KCNQ1-KCNE1 channel directly interacts with microtubules and that this interaction plays a major role in coupling PKA-dependent phosphorylation of KCNQ1 with I(Ks) activation.
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Nicolas et al. (2008) studied this question.
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