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November 14, 2013Journal of VirologyOpen Access

TMPRSS2 and ADAM17 Cleave ACE2 Differentially and Only Proteolysis by TMPRSS2 Augments Entry Driven by the Severe Acute Respiratory Syndrome Coronavirus Spike Protein

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Authors

AHAdeline HeurichColumbia CollegeHHHeike Hofmann-WinklerGerman Primate CenterSGStefanie GiererGerman Primate Center

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Heurich et al. (2013) studied this question.

synapsesocial.com/papers/69da8c2c387cf70698686e61https://doi.org/10.1128/jvi.02202-13
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  3. 3Proteolytic Release of Membrane-Bound Angiotensin-Converting Enzyme: Role of the Juxtamembrane Stalk Sequence1996 · 69 citations
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  5. 5Influenza and SARS-Coronavirus Activating Proteases TMPRSS2 and HAT Are Expressed at Multiple Sites in Human Respiratory and Gastrointestinal Tracts2012 · 424 citations