Genetic association study reveals APOE polymorphisms influence plasma lipids in an Algerian population, suggesting rs4420638 G allele mitigates ε4-associated LDL-cholesterol elevation.
Our results showed that (i) the APOE epsilon polymorphism has the expected impact on the plasma lipid profile and (ii) the rs4420638 G allele may counterbalance the deleterious effect of the ε4 allele on LDL-cholesterol levels in an Algerian population.
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Boulenouar et al. (2013) studied this question.
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