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January 1, 2003Arthritis ResearchOpen Access

Aggrecanases and cartilage matrix degradation.

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Authors

HNHideaki NagaseVascular Medicine MKMasahide KashiwagiWaseda University

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Implication

Targeting ADAMTS aggrecanases could slow early cartilage loss in RA/OA; leaves open isoform-selective inhibition in trials.

Key Points

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Cite This Study

Nagase et al. (2003) studied this question.

synapsesocial.com/papers/69da94f20f0ab7a47c835bb0 https://doi.org/10.1186/ar630

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1The 45 kDa collagen-binding fragment of fibronectin induces matrix metalloproteinase-13 synthesis by chondrocytes and aggrecan degradation by aggrecanases2002 · 115 citations
2Processing of the Notch Ligand Delta by the Metalloprotease Kuzbanian1999 · 418 citations
3Cleavage of aggrecan at the Asn341-Phe342 site coincides with the initiation of collagen damage in murine antigen-induced arthritis: A pivotal role for stromelysin 1 in matrix metalloproteinase activity1999 · 114 citations
4The interglobular domain of cartilage aggrecan is cleaved by PUMP, gelatinases, and cathepsin B.1992 · 299 citations
5Articular cartilage and changes in arthritis: matrix degradation.2001 · 173 citations