Review examines blood-brain barrier disruption and reperfusion injury in acute ischemic stroke, highlighting pathways leading to hemorrhagic transformation.
It has been more than a century since Paul Ehrlich, in 1885, and later his student Edwin Goldmann, proposed that a barrier existed between the CNS and the peripheral circulation. 1 While studying the limited permeation of potassium ferrocyanate into the brain in 1900, Lewandowsky coined the term bluthirnschranke, blood-brain barrier (BBB).
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Khatri et al. (2012) studied this question.
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